
Our nails are made of a tough, rigid protein called alpha-keratin, which is also found in claws, hooves, and horns of vertebrates. The nail matrix is the active tissue that generates cells, and it is located under the base portion of the fingernail, where the cuticle is. The cells in the nail matrix manufacture keratin, which builds up and causes the nail to grow outward from the nail root to the nail plate. The nail bed is the skin beneath the nail plate, and it is highly innervated, which is why removing the nail plate is often painful. The nail functions to protect the fingertip and surrounding soft tissues from injuries and also aids in tactile sensation. While nails grow outward, they do not extend far beyond the tip of the fingers.
| Characteristics | Values |
|---|---|
| Purpose | Protect the distal phalanx, the fingertip, and the surrounding soft tissues from injuries |
| Composition | Tough rigid protein called alpha-keratin |
| Parts | Nail plate, nail matrix, nail bed, nail wall, lateral margin, nail groove or fold, paronychium, hyponychium |
| Nail Matrix Composition | Special cells that produce 196 layers of cells that combine to make each of your fingernails and toenails |
| Nail Bed Composition | Dermis and epidermis |
| Nail Growth | Caused by the buildup of proteins on top of the nail matrix, with new cells pushing older ones forward and out |
| Nail Function | Help with tactile sensation |
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What You'll Learn

Nails are made of a protein called alpha-keratin
The human body produces 54 types of keratin, a protein that helps keep your hair, skin, and nails healthy and strong. Keratin is also found in animal bodies and is present in feathers, claws, beaks, and scales. Keratin is a crucial structural component in nails, providing strength, toughness, and resilience. It is made up of long chains of amino acids, specifically cysteine, methionine, and phenylalanine, which form a helical structure that gives keratin its rigidity and strength.
Nails are made up of a protein called alpha-keratin, which is also found in hair, skin, and the wool of mammals. Alpha-keratin is the predominant type of keratin in human nails, providing them with strength and hardness. It is fibrous and has a helical structure, which means it looks like the thread of a screw. The nail matrix, where nail growth begins, plays a crucial role in producing alpha-keratin. This region contains specialized cells that continuously divide and produce keratinocytes, the building blocks of keratin.
The structure and appearance of nails are determined by the amount and arrangement of alpha-keratin within them. Ensuring a balanced diet rich in protein and essential vitamins is crucial for promoting healthy nail growth. Proper nutrition, adequate hydration, and stress management are all important factors that influence the health of nails and the process of keratinization.
While nails serve functional and aesthetic purposes, issues such as infections or trauma can lead to discomfort, pain, and even serious health concerns. Understanding the composition of nails and the role of alpha-keratin can help shed light on their importance in our daily lives, such as aiding in grasping objects and providing support to our fingers and toes. Protecting the hands and nails from injuries and managing health conditions that affect the nails are important aspects of nail care.
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The nail matrix is the active tissue that generates cells
The nail matrix is a critical component of nail anatomy, responsible for generating new cells that form our fingernails and toenails. It is located at the base of the nail, and while most of it is hidden from view, the lunula, or the white crescent shape at the nail's base, is a visible part of the nail matrix. This area is responsible for creating new skin cells, pushing out old, dead skin cells, and facilitating nail growth.
The nail matrix consists of two parts: the germinal matrix and the sterile matrix. The germinal matrix, located below the lunula, is the most active region, contributing to approximately 90% of nail production. It gives the nail its natural curvature. The sterile matrix, situated above the lunula, accounts for the remaining 10% of nail cells and plays a crucial role in keeping the nail attached to the underlying skin.
The nail matrix is susceptible to various injuries and conditions that can impact nail growth. Trauma to the nail matrix, such as a deep cut or injury to the germinal matrix, can cause nail cell production to cease temporarily or, in severe cases, permanently. Fingernail injuries are often associated with broken fingers, while ingrown nails can result from nails cut too short, trauma, or tight shoes.
Certain health conditions, such as fungal infections, can affect the nail matrix, leading to thickened, yellow, cracked, or cloudy nails. Illnesses like heart attacks, COVID-19, or pneumonia can also interrupt nail growth and cause Beau's lines, which are horizontal ridges on the nails. Additionally, chemotherapy and other medications can cause Beau's lines or slow nail growth and may lead to Mees' lines (white bands across the nails) and nail colour changes.
The nail matrix is a vital structure for nail health, and its proper functioning is essential for maintaining healthy nails. Protecting the nail matrix from injury and managing any underlying health conditions that could affect it are crucial steps in nail care.
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Nails help with tactile sensation
The nail bed (or sterile matrix) is the soft tissue that lies underneath the nail plate, attaching it to the distal phalanx. The nail bed provides a smooth surface for the growing nail to slide over. The germinal matrix is an area of soft tissue proximal to the sterile matrix. The cells within the germinal matrix divide and become keratinised to form the nail plate.
Nails play an important role in tactile sensation, which is one of our eight senses. Tactile sensation allows us to process information from our surroundings through receptors on our skin. Our tactile sense responds to touch, pressure, pain, vibration, and temperature.
The skin receives information about light touch, discriminative touch, touch pressure, pain, temperature, and vibration. Each of these sensations provides different qualities of sensation and plays different roles. For example, light touch and pain typically warn the body about potential threats and are therefore often called "protective sensations". They are particularly sensitive to touch, and their sensory information is taken along a different nerve pathway to discriminative touch sensations.
Some individuals are sensitive to touch and may respond by avoiding certain sensations or having a bigger reaction than expected. For example, they may refuse to wear socks with seams because the texture irritates their skin. Tactile defensiveness is a term used to describe the reaction that occurs when someone is very sensitive to touch. Their brains may interpret ordinary touch sensations, such as clothing textures or hugs, as a threat, triggering a fight, flight, or freeze response.
There are strategies that can help individuals with tactile defensiveness regulate their sensory systems, such as firm or deep pressure input and exploring different textures.
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The nail bed is the skin beneath the nail plate
The nail bed is an important part of the nail structure, playing a crucial role in both the appearance and health of the nail. It is rich in blood and lymph vessels and nerve endings, which help to keep the nail plate healthy and protected. The blood vessels supply food, oxygen, and nutrients to the fingernail, while the lymph vessels help to protect the nail from allergens and pathogens.
The nail bed is susceptible to damage and infection if not properly cared for. Biting your nails can leave the nail bed tissue exposed, which can be extremely painful and lead to health complications such as inflammation. It is important to keep the nails and the skin around them moisturized to prevent cracking and infection. Proper nail care, including regular inspection and maintenance, is essential for promoting healthy, strong, and aesthetically pleasing nails.
The nail bed is connected to many other systems of the nail, including the series of matrices that help to grow the nail bed found below the surface of the skin past the nail plate. These interconnecting systems work together to keep the nails and skin safe. By understanding the distinction between the nail plate and the nail bed, nail professionals can offer safe and effective nail services to their clients.
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The nail wall is the cutaneous fold overlapping the sides and proximal end of the nail
The nail is a protective plate found at the tip of the fingers and toes of all primates, corresponding to the claws in other animals. The nail consists of the nail plate, the nail matrix, and the nail bed below it, along with the grooves surrounding it. The nail matrix is the active tissue that generates cells, with the cells hardening as they move outward from the nail root to the nail plate. The nail matrix is also known as the matrix unguis, keratogenous membrane, or onychostroma. It is the part of the nail bed that lies beneath the nail and contains nerves, lymph, and blood vessels.
The nail wall, also known as the lateral nail fold, is the cutaneous fold that overlaps the sides of the nail. The proximal nail fold, on the other hand, is the skin bordering the lower end of the nail, located at the bottom of the nail. It frames the nail along with the lateral nail folds. The proximal nail fold is a wedge of thickened skin at the base of the nail and is found on both fingernails and toenails. The skin folds over the nail matrix and the base of the nail, protecting the nail as it grows.
The nail matrix is located deep inside the proximal nail fold. The top of the proximal nail fold has normal skin, while the underside has thinner skin. The proximal nail fold and cuticle create a seal between the matrix and the nail, protecting the area from harmful germs. The cuticle, a thin layer of skin, grows over the nail at the proximal nail fold. The cuticle should not be cut, according to the American Academy of Dermatology (AAD), as cutting it will increase the risk of infection.
The lateral margin lies beneath the nail wall on the sides of the nail, and the nail groove or fold (sulcus matricis unguis) are the cutaneous slits into which the lateral margins are embedded. The paronychium, the soft tissue border around the nail, overlaps onto the sides of the nail plate and is the site of hangnails, ingrown nails, and paronychia, a skin infection. The hyponychium is the thickened portion of the area of epithelium underlying the free edge of the nail plate.
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Frequently asked questions
Nails are attached to the nail bed, which is the skin beneath the nail plate. The nail bed is made of two types of tissues: the dermis and the epidermis. The epidermis is the outermost layer of skin and is only a few cells thick. The nail and nail bed separate at the tip of the finger or toe.
The nail bed is the area of the nail on which the nail plate rests. It is made of skin cells and supplies nourishment to the entire nail unit.
Nails help us with tactile sensation. When you touch something, the nail pushes back from the other side, and the pressure helps the nerve cells activate. Nails also protect the fingertip and the surrounding soft tissues from injuries.
Nails are made of a tough, rigid protein called alpha-keratin, a polymer also found in the claws, hooves, and horns of vertebrates.











































