
Hand, foot and mouth disease (HFMD) is a mild, contagious viral infection that is most common in children. It is characterised by fever, sores or blisters in the mouth, and a rash on the hands and feet. In some cases, the disease can cause nail changes, or onychomadesis, which can develop 28 to 56 days after infection. This article will explore the timeline of nail peeling after HFMD and provide insights into the recovery process.
| Characteristics | Values |
|---|---|
| Nail changes | Onychomadesis, Beau's lines, yellowish-orange discolouration of the nail plate |
| Time taken for nail changes to occur | 4-8 weeks after disease onset |
| Time taken for nails to return to normal | 1-4 months |
| Percentage of severe cases that result in nails falling off | 4% |
| Time taken for nails to fall off in severe cases | 3-6 weeks |
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What You'll Learn
- Nail changes occur 4-8 weeks after disease onset
- Onychomadesis is a nail-bed separation, usually followed by incomplete shedding
- Beau's lines are horizontal grooves across the nail plate
- Yellowish-orange discolouration of the nail plate
- Nail abnormalities are not permanent, and normal growth occurs within 1-4 months

Nail changes occur 4-8 weeks after disease onset
Hand-foot-and-mouth disease (HFMD) is a mild, contagious viral infection that is most common in children. It is caused by a group of coxsackieviruses, chiefly coxsackievirus A16 and Human enterovirus 71. The symptoms include fever, mouth sores, and a rash on the hands and feet.
Nail changes, or onychomadesis, can occur following HFMD. Onychomadesis is a phenomenon in which the nail plate separates from the nail bed due to a cessation of activity in the nail matrix, usually followed by incomplete shedding of the nail. Nail changes typically occur 4-8 weeks after the onset of the disease. During this time, individuals may notice Beau's lines, which are horizontal grooves running across the nail plates, as well as discolouration of the nails, which may appear yellowish-orange or grey-white.
In one case, a seven-year-old boy presented with nail changes three weeks after recovering from HFMD. Initially, a grey-white patch appeared on the bottom of his nails and spread, and eventually, his nails shed completely or partially. Fresh, thin pink nails grew slowly in their place.
While nail changes following HFMD can be alarming, they are not permanent. Normal nail growth typically occurs within one to four months. To promote healing, individuals can apply a moisturizing cream to the affected nails and surrounding skin.
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Onychomadesis is a nail-bed separation, usually followed by incomplete shedding
Hand, foot, and mouth disease (HFMD) is a mild, contagious viral infection common among children. It is caused by a group of coxsackieviruses, chiefly coxsackievirus A16 and Human enterovirus 71. The disease is characterised by fever and eruptions over the palms, soles, knees, buttocks, and oral mucosa. Nail changes, such as onychomadesis, can occur 4–8 weeks after the onset of the disease.
Onychomadesis is a nail phenomenon characterised by the separation of the nail plate from the nail bed, usually followed by incomplete shedding of the nail. The separation occurs due to the cessation of activity in the nail matrix, which can be caused by medication exposures, trauma, physiological stress, or viral infections. In the context of HFMD, onychomadesis can develop 28 to 56 days after the initial infection, and changes in the nails are not permanent. Normal nail growth typically resumes within one to four months.
The nail bed changes that occur in onychomadesis typically commence 3 to 12 weeks after a Coxsackie virus infection. This condition can affect both the fingernails and toenails, even on digits not directly impacted by the illness. The nails may exhibit white or yellow streaks on the medial and lateral nail beds, transverse nail splitting, and nail shedding. Additionally, onychomadesis is associated with nail plate fragmentation, which can lead to inflammation of the nail bed. Ultrasound images reveal thickening of the dermis of the proximal nail fold and a hypoechoic halo in the big toes.
It is important to distinguish onychomadesis from similar nail conditions. Onycholysis, for example, also involves the separation of the nail plate from the nail bed. However, onycholysis typically starts at the distal end of the nail or the sides, unlike onychomadesis, which begins at the proximal nail fold. Onychomycosis, on the other hand, is an infection of the nail caused by a dermatophyte, resulting in thickened, discoloured, and brittle nails. However, onychomycosis does not lead to nail separation from the nail bed.
In summary, onychomadesis is a nail condition characterised by nail bed separation and subsequent incomplete shedding. It is often associated with HFMD, occurring several weeks after the initial infection. The condition resolves spontaneously, and normal nail growth resumes within a few months. It is important to differentiate onychomadesis from other nail conditions, such as onycholysis and onychomycosis, based on the specific characteristics of nail changes and the probable exposure to HFMD.
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Beau's lines are horizontal grooves across the nail plate
Hand, foot, and mouth disease (HFMD) is a mild, contagious viral infection common among children. It is caused by a group of coxsackieviruses, chiefly coxsackievirus A16 and Human enterovirus 71. The disease is characterised by fever and eruptions over the palms, soles, knees, buttocks, and oral mucosa. Changes in the nails, such as Beau's lines, occur 4-8 weeks after the onset of the disease. Beau's lines are horizontal grooves or ridges that appear on the nail plate, running from side to side on the fingernail or toenail. They are named after French physician Joseph Honoré Simon Beau, who first described them in 1846. Beau's lines are not to be confused with vertical ridges that run from the cuticle to the fingertip, which are usually a natural consequence of aging.
Beau's lines are caused by a sudden interruption in nail growth, often due to an injury, illness, or skin condition. They can also be caused by severe stress, certain medications, or chronic conditions that interfere with blood flow to the nail matrix, such as hypothyroidism, peripheral artery disease, or Raynaud's phenomenon. In the case of hand, foot, and mouth disease, the nail changes are thought to occur due to temporary inhibition of nail matrix activity as a result of inflammation from periungual HFMD lesions.
The appearance of Beau's lines can vary, with thickness and number providing clues about the underlying cause. A single Beau's line on one nail may indicate an injury that affected only one finger or toe, while lines on all nails can suggest an illness or stress as the cause. Multiple Beau's lines on each nail may indicate repeated or prolonged illness or trauma. While Beau's lines themselves are not harmful, they are a sign of an underlying issue. Treating the underlying cause will allow smooth nails to grow again.
There is no specific treatment for Beau's lines, but the underlying cause should be addressed to prevent their recurrence. Beau's lines will usually go away as the nails grow out, and the nail growth will return to normal once the underlying cause is resolved. If the grooves are cosmetically bothersome, they can be filled in with gel nails followed by gentle buffing. However, it is important to use nail products with caution as some can weaken or damage nails.
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Yellowish-orange discolouration of the nail plate
Hand, foot, and mouth disease (HFMD) is a mild, contagious viral infection that affects children. It is caused by a group of coxsackieviruses, mainly coxsackievirus A16 and Human enterovirus 71. HFMD is characterised by fever and eruptions over the palms, soles, knees, buttocks, and oral mucosa. One of the characteristic nail changes observed 4-8 weeks after the onset of the disease is a yellowish-orange discolouration of the nail plate, known as onychomycosis, which affects multiple fingers and toenails.
Onychomycosis is an infection of the nail, usually caused by a dermatophyte. It affects about 10% of the US population. While it is not life-threatening, it can cause pain and negatively impact an individual's quality of life. Onychomycosis typically leads to thickened, discoloured, and brittle nails, but notably, the nails do not separate from the nail bed. The discolouration becomes worse in tight-fitting shoes or trauma to the nail plates and is often associated with athlete's foot.
Yellow nail syndrome is another potential cause of yellowish-orange discolouration of the nail plate. This syndrome has been observed as an adverse reaction to certain drugs, such as quinaqrine used for cutaneous lupus erythematosus, topical use of 5-fluorouracil for nail psoriasis, temsirolimus, bucillamine for rheumatoid arthritis, and retinoids. Additionally, yellow nail syndrome has been reported during hemodialysis and in patients diagnosed with non-Hodgkin lymphoma.
In some cases, yellowish-orange discolouration of the nail plate may be a result of fungal infections. The most common fungal infection is from the Trichophyton family, which can cause thickening and deformity of the nail plate, leading to discolouration. To treat such infections, it is recommended to avoid moist environments, wear comfortable and properly fitted shoes, and use antifungal medications, preferably in oral form, for at least three months to ensure effectiveness.
Furthermore, onycholysis, a condition where the tip of the nail plate lifts off the nail bed, can also result in yellowish discolouration. This occurs when the nail bed is exposed to air, and common causes include trauma, psoriasis, or side effects of certain medications. Occupations that require frequent handwork, such as butchers, food handlers, and hairdressers, are more prone to onycholysis. To manage this condition, it is advisable to avoid trauma to the nails, wear protective gloves, stay away from moist environments, and keep your nails trimmed without cleaning underneath them.
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Nail abnormalities are not permanent, and normal growth occurs within 1-4 months
Hand-foot-and-mouth disease (HFMD) is a mild, contagious viral infection that affects children. It is caused by a group of coxsackieviruses, chiefly coxsackievirus A16 and Human enterovirus 71. Symptoms include fever, rashes, and mouth sores or blisters. Nail abnormalities are a common occurrence after contracting hand-foot-and-mouth disease. These abnormalities are characterised by onychomadesis, Beau's lines, and yellowish-orange discolouration of the nail plate.
Onychomadesis is a condition where the nail plate separates from the nail bed, resulting in partial or complete nail shedding. It typically develops 28 to 56 days after recovering from hand-foot-and-mouth disease. Initially, a grey-white patch appears on the bottom of the nails, followed by nail shedding from the bottom to the free border of the nail. During this process, fresh, thin pink nails grow slowly underneath. Beau's lines are horizontal grooves that run across the nail plates, giving the nails a cloudy, grey-white colour.
Nail abnormalities associated with hand-foot-and-mouth disease are not permanent. Normal nail growth typically occurs within one to four months. During this period, it is important to take care of the nails and skin by using moisturising cream on the raw skin. Keeping the hands and feet hydrated can help soothe the affected areas and promote healing.
It is worth noting that nail abnormalities during childhood are generally uncommon outside of hand-foot-and-mouth disease. Other causes of onychomadesis include trauma or injury, systemic disease, infection, drug use, radiation, and chemotherapy. Understanding the underlying cause of onychomadesis is crucial for providing appropriate treatment and ensuring the overall well-being of the affected individual.
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Frequently asked questions
Nails can start to peel between 28 and 56 days after infection with hand, foot, and mouth disease.
Nails may develop Beau's lines, which are horizontal grooves running across the nail plates, and a cloud-like, grey-white colour.
Nail abnormalities are not permanent, and normal nail growth typically occurs within one to four months.











































