
Human nails are composed of a tough, rigid protein called alpha-keratin, which is also found in hair and skin. Unlike bones, which are made of collagen, nails are made of dead, compacted cells that cause them to be strong yet flexible. The shape of the nail is determined by the underlying bone, and the growth rate of nails is related to the length of the terminal phalanges (outermost finger bones). While nails are not made of bone, they can provide valuable insight into bone health. For example, nail samples can be used to identify patients with osteogenesis imperfecta (OI), a genetic metabolic disorder that affects bone collagen synthesis.
| Characteristics | Values |
|---|---|
| What are nails made of? | Nails are made of a tough rigid protein called alpha-keratin, a polymer also found in the claws, hooves, and horns of vertebrates. |
| What are bones made of? | Bones are made mostly of collagen. |
| What is the growth rate of nails? | Nails grow at a rate of about 3 millimeters per month, and toenails grow a little slower. The growth rate of nails is related to the length of the terminal phalanges (outermost finger bones). |
| What is the shape of the nail determined by? | The shape of the nail is determined by the form of the underlying bone. |
| What is the nail bed? | The nail bed is the skin beneath the nail plate. It is the area of the nail on which the nail plate rests. |
| What is the lunula? | The lunula ("small moon") is the whitish crescent-shaped base of the visible nail. |
| What is the matrix? | The matrix is the active tissue that generates cells. |
| What is the hyponychium? | The hyponychium is the epithelium located beneath the nail plate at the junction between the free edge and the skin of the fingertip. |
| What is the onychodermal band? | The onychodermal band is the seal between the nail plate and the hyponychium. |
| What is the proximal nail fold? | The skin bordering the lower end of the nail is called the proximal nail fold. |
| Can nails be used to diagnose bone health? | Physicochemical properties of nails may offer valuable insight into the health of bones. |
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What You'll Learn
- Nails are made of keratin, a tough rigid protein
- Bones are made of collagen, a different type of protein
- Nails protect the tips of our fingers and aid our sense of touch
- The growth rate of nails is related to the length of the terminal phalanges (outermost finger bones)
- The health of nails may offer insight into bone health

Nails are made of keratin, a tough rigid protein
Nails are made of a tough, rigid protein called alpha-keratin, which is also found in the claws, hooves, and horns of vertebrates. Keratin is a crucial protein that serves as the main structural component in nails, giving them their strength and resilience. It is made up of long chains of amino acids, specifically cysteine, methionine, and phenylalanine, which form a helical structure that gives keratin its strength and rigidity.
The nail consists of the nail plate, the nail matrix, and the nail bed below it, and the grooves surrounding it. The nail matrix is the active tissue that generates cells, which harden as they move outward from the nail root to the nail plate. The nail plate, or nail body, is the visible hard nail area made of translucent keratin protein. Several layers of dead, compacted cells cause the nail to be strong but flexible, and its shape is determined by the form of the underlying bone.
Keratin is also found in hair and the outer layer of our skin, as well as in glands and organs. It is produced naturally by the body and can be strengthened by eating keratin-rich foods. The two main types of keratin are alpha-keratin and beta-keratin. Alpha-keratin is the type found in human hair and nails, providing strength and hardness, while beta-keratin is more common in the animal kingdom, found in scales, feathers, and beaks.
The health of our nails can be influenced by several factors, including diet, hydration levels, stress levels, and overall health. A balanced diet rich in protein and essential vitamins is crucial for promoting healthy nail growth, and proper hydration is essential for nail health. High stress levels can negatively impact nail health, and certain deficiencies, such as low dietary protein intake or a lack of omega-3 fatty acids, can contribute to brittle, dry, or discoloured nails.
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Bones are made of collagen, a different type of protein
While nails are made of a tough, rigid protein called alpha-keratin, bones are made of collagen, a different type of protein. Collagen is a vital component of bone matter and is required for strong and supple joints, skin, hair, and bones. It is also needed for healthy cartilage.
Collagen is a popular supplement that comes in the form of powder and capsules. It is often mixed with beverages and food. Collagen supplements are available in various forms, such as salted caramel collagen peptides, bone broth collagen, and grass-fed bone broth collagen.
Collagen supplements provide a substantial protein boost and support muscle recovery and daily nutrition needs. They also help maintain joint health and mobility by providing collagen-rich nutrients. Additionally, they nourish hair, skin, and nails, improving their overall health and appearance.
Collagen is particularly beneficial for the digestive system, as it can restore the gut lining, support the growth of healthy bacteria, and provide trace minerals and amino acids. It also helps repair tendons and ligaments, lubricates joints, and supports bone matter.
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Nails protect the tips of our fingers and aid our sense of touch
Unlike bones, which are made of collagen, nails are made of a protein called keratin, which also forms the cells of our hair and skin. Nails are not just cosmetic features, but essential tools that aid in daily activities. They provide strength and protection to our fingertips and help us with fine motor movements. The hard and durable structure of nails allows for increased pressure and stability when gripping objects. They act as a shield, preventing direct contact with potentially harmful substances and reducing the risk of damage to the underlying tissues.
Nails also play a crucial role in our sense of touch. They contain a network of sensitive nerves that enable us to feel texture, pressure, and temperature. The sense of touch allows us to gather information about our surroundings and is required for normal cognitive development. Touch is an intimate sense, as it requires direct contact with the skin, which is the sensory organ of tactile sensation.
The development of broad fingertips, supported by the presence of fingernails, has improved our grip and fine motor skills over time. Nails have evolved to serve multiple purposes, including protection and sensory feedback. Their versatility has been instrumental in the success of our species, allowing us to adapt and thrive in various environments.
Proper nail care is essential, as nails reflect our overall health. Keeping nails clean, dry, and shaped helps prevent bacterial and fungal infections. Nails should be cut straight across and rounded slightly at the tips for maximum strength.
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The growth rate of nails is related to the length of the terminal phalanges (outermost finger bones)
The growth rate of nails is also influenced by various other factors. For instance, nails grow faster in summer than in winter, possibly due to the vitamin D that accompanies sunlight, which helps with the intake of phosphorus, calcium, and magnesium. The actual growth rate of nails is also dependent on age, sex, exercise level, diet, and hereditary factors.
Nail growth can be an indicator of health. For example, nail growth records can show the history of recent health and physiological imbalances, and have been used as a diagnostic tool since ancient times. Changes in nail appearance, such as discolouration, thinning, thickening, brittleness, and grooves, can indicate illness in other areas of the body, nutrient deficiencies, or drug reactions.
Nail biting, or onychophagia, usually doesn't cause long-term damage, but it can increase the risk of getting sick by spreading germs to the mouth. To keep nails healthy, it's important to take breaks from using nail polish or having artificial nails, as these products can be hard on nails and hinder their ability to repair themselves.
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The health of nails may offer insight into bone health
The human nail is a protective plate found at the tip of the digits (fingers and toes). Unlike bones, which are made mostly of collagen, nails are made of a tough rigid protein called alpha-keratin. The growth rate of nails is related to the length of the terminal phalanges (outermost finger bones). The index finger's nail grows faster than that of the little finger, and fingernails grow up to four times faster than toenails.
The health of nails may offer valuable insight into bone health. Physicochemical properties of nails may provide insight into the health of bones. While dual-energy X-ray absorptiometry (DXA) is the standard technique for evaluating bone health through bone mineral density (BMD), it only explains 70% of fractures. The World Health Organization has recommended the development of alternative methods of assessing bone health. Keratin and collagen type I are major proteins in nails and bones, respectively, and both undergo post-translational modifications. Raman spectroscopy can detect changes in protein composition and structure, which may be associated with the development of osteoporosis. Thus, it may be a valuable tool for assessing bone health and fracture risk.
However, variations in physicochemical properties, as well as differences in nail growth speed, limit the use of nail mineral content to evaluate bone health. Studies have not been consistent, and the measurement of nail plate protein and minerals cannot yet be considered a routine practice for screening bone disorders.
Nail mineral and protein content might be a useful alternative or complementary method for the screening and detection of bone metabolism disorders. For example, Bahreini et al. used laser breakdown spectroscopy (LBS) to measure the elemental composition of fingernails in 99 subjects, investigating the association between fingernail minerals and BMD. While the results demonstrated a relationship between nail mineral composition (calcium) and BMD, the validation results were not promising.
In conclusion, while the physicochemical properties of nails may offer valuable insights into bone health, further research and alternative methods are needed to fully understand the relationship between nail and bone health.
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Frequently asked questions
No, finger nails are not made of bone. Nails are made of a tough, rigid protein called keratin, whereas bones are made of collagen.
Nails are protective plates found at the tip of the digits (fingers and toes) of all primates, corresponding to the claws in other tetrapod animals. They can be used as tools, for scratching, and for opening things.
Nails grow at a rate of about 3 millimeters per month, and toenails grow a little slower. The growth rate depends on factors such as age, sex, season, exercise level, diet, and hereditary factors.
Fingernails grow up to four times faster than toenails. The average growth rate for fingernails is 3.5 mm per month, while for toenails, it is approximately 1.6 mm per month.
Yes, the physicochemical properties of nails may offer valuable insight into bone health. The amino acid profile of nail keratin, for example, can indicate whether a sample is from a fracture or not.










































